Curvilinearity provides additional information to lung clearance index only in a minority of children with early cystic fibrosis lung disease

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Curvilinearity provides additional information to lung clearance index only in a minority of children with early cystic fibrosis lung disease

By FYH News Team

Published on April 11, 2022

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. 2022 Apr 4;8(2):00582-2021.

doi: 10.1183/23120541.00582-2021.

eCollection 2022 Apr.

Affiliations

Free PMC article

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Samantha Irving et al.

ERJ Open Res.

2022.

Free PMC article

. 2022 Apr 4;8(2):00582-2021.

doi: 10.1183/23120541.00582-2021.

eCollection 2022 Apr.

Affiliations

¹ Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.
² Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK.
³ These authors contributed equally.
⁴ Children’s Hospital at Westmead, Respiratory, Sydney, Australia.

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Abstract

Curvilinearity, as calculated from multiple-breath washout, is abnormal in a small number of children with cystic fibrosis when other tests are still normal https://bit.ly/3p9QAV4.

Conflict of interest statement

Conflict of interest: S. Irving has nothing to disclose. Conflict of interest: K. Bayfield has nothing to disclose. Conflict of interest: J.C. Davies has nothing to disclose. Conflict of interest: A. Bush has nothing to disclose.

Figures

**FIGURE 1**

Curvilinearity (Curv) *versus* lung clearance index (LCI) in patients with cystic fibrosis. a) The overall result is not linear. b) The correlation between LCI and Curv in patients with mild changes (LCI<10 Pearson’s r of 0.8, p<0.001). c) There is no correlation between LCI and Curv at higher LCI values. ^#: outliers, shown in both relevant panels. ***: p<0.001.

References

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Affiliations

Affiliations

Abstract

Conflict of interest statement

Figures

References

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