The effectiveness of Global Wellness (combined mental and physical health) among samples of primarily White clients is well-documented in the literature. However, the Global Wellness literature is lacking research among ethnic minority populations who tend to face healthcare inequities. For example, Black and Latinx adults in the U.S. face inequities in the quality and accessibility of mental and physical healthcare services, including unique risks for anxiety and depression. In this study, a national random sample, (N = 4,009) was recruited (stratified by age, gender, and geographic region of the U.S.) of Latinx and Black adults to examine the association between Anxiety Severity and Depression Severity with Global Wellness as well as demographic differences in Global Wellness. Anxiety and depression emerged as significant negative predictors of Global Wellness and results revealed a number of demographic differences in Global Wellness. Implications for counseling practice and how mental health counselors can reduce healthcare disparities are discussed.