Though sexual assault is prevalent among college campuses, there is a paucity of research on whether risk factors vary for different racial/ethnic groups. As such, this article examines familial and individual risk factors and three sexual assault types (coercive, physically forced, and incapacitated) with depressive symptoms and post-traumatic stress disorder (PTSD) symptoms to see whether such risks vary for Black/African American, White, Asian, and Hispanic groups of college students. Data were gathered in 2019 to 2020 from 783 undergraduate college women and men at a large public university in the Midwestern United States. Results revealed that in terms of family background, Black/African American, Asian, and Hispanic students reported more experiences of child physical abuse and lower levels of warmth and support compared to White students. White college students, however, reported more frequent heavy drinking compared to Asian and Hispanic students. For sexual assault, Asian students reporting experiencing incapacitated sexual assault more so than White students, whereas Black/African American students reported experiences of physically forced sexual assault more so than White students. For mental health, Hispanic students reported more PTSD symptoms compared to White students while Asian students reported more depressive symptoms compared to their White counterparts. It is noteworthy that early experiences of child physical abuse and lower warmth and support continued to significantly impact both PTSD symptoms and depressive symptoms. Our results demonstrate the importance of going beyond the typical dichotomy of White and non-White to gain a more nuanced understanding of how risk factors vary for different racial and ethnic groups, which has implications for intervention and prevention when understanding sexual assault and mental health outcomes.