Identifying and overcoming barriers to participation of minority populations in clinical trials: Lessons learned from the VanDAAM study

By FYH News Team

Published on July 7, 2022

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doi: 10.1002/cam4.5000.

Online ahead of print.

Angelina K C Fink¹, Amanda C DeRenzis¹, Shivanshu Awasthi¹, Nawreen Jahan², Peter A S Johnstone³, Julio Pow-Sang⁴, Javier Torres-Roca³, Daniel Grass³, Daniel Fernandez³, Arash Naghavi³, Susan Tan³, Brandon Manley⁴, Roger Li⁴, Michael Poch⁴, Alice Yu⁴, Nikki Little⁴, Eppie Bass⁴, Cesar E Ercole⁵, Evangelia Katsoulakis⁶, Ryan Burri⁷, Riley Smith¹, Nathanael B Stanley⁸, Susan T Vadaparampil^{8

9}, Kosj Yamoah^{1

3}

Affiliations

¹ Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
² Tallahassee Memorial Hospital, Tallahassee, Florida, USA.
³ Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁴ Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁵ Urology Section, James A. Haley Veterans’ Hospital, Tampa, Florida, USA.
⁶ Radiation, James A. Haley Veterans’ Hospital, Tampa, Florida, USA.
⁷ Radiation, Bay Pines VA Healthcare System, Bay Pines, Florida, USA.
⁸ Office of Community Outreach, Engagement & Equity (COEE), H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁹ Health Outcomes & Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

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Angelina K C Fink et al.

Cancer Med.

2022.

doi: 10.1002/cam4.5000.

Online ahead of print.

Authors

Affiliations

¹ Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
² Tallahassee Memorial Hospital, Tallahassee, Florida, USA.
³ Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁴ Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁵ Urology Section, James A. Haley Veterans’ Hospital, Tampa, Florida, USA.
⁶ Radiation, James A. Haley Veterans’ Hospital, Tampa, Florida, USA.
⁷ Radiation, Bay Pines VA Healthcare System, Bay Pines, Florida, USA.
⁸ Office of Community Outreach, Engagement & Equity (COEE), H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
⁹ Health Outcomes & Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

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Abstract

Participation in cancer research trials by minority populations is imperative in reducing disparities in clinical outcomes. Even with increased awareness of the importance of minority patient inclusion in clinical research to improve cancer care and survival, significant barriers persist in accruing and retaining minority patients into clinical trials. This study sought to identify and address barriers to minority accrual to a minimal risk clinical research study in real-time.

Keywords:

African American men (AAM); Decipher; VanDAAM; minority populations; prostate cancer (PCa).

References

REFERENCES

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30.
1. Edwards BK, Noone AM, Mariotto AB, et al. Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 2014;120(9):1290-1314.
1. DeSantis CE, Siegel RL, Sauer AG, et al. Cancer statistics for African Americans, 2016: progress and opportunities in reducing racial disparities. CA Cancer J Clin. 2016;66(4):290-308.
1. Tsodikov A, Gulati R, de Carvalho TM, et al. Is prostate cancer different in black men? Answers from 3 natural history models. Cancer. 2017;123(12):2312-2319.
1. Shenoy D, Packianathan S, Chen AM, Vijayakumar S. Do African-American men need separate prostate cancer screening guidelines? BMC Urol. 2016;16(1):19.

Affiliations

Authors

Affiliations

Abstract

References

REFERENCES

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