Modelling prevalent cardiovascular disease in an urban Indigenous population

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Objective:

Studies have highlighted the inequities between the Indigenous and non-Indigenous populations with respect to the burden of cardiovascular disease and prevalence of predisposing risks resulting from historical and ongoing impacts of colonization. The objective of this study was to investigate factors associated with cardiovascular disease (CVD) within and specific to the Indigenous peoples living in Toronto, Ontario, and to evaluate the reliability and validity of the resulting model in a similar population.


Methods:

The Our Health Counts Toronto study measured the baseline health of Indigenous community members living in Toronto, Canada, using respondent-driven sampling. An iterative approach, valuing information from the literature, clinical insight and Indigenous lived experiences, as well as statistical measures was used to evaluate candidate predictors of CVD (self-reported experience of discrimination, ethnic identity, health conditions, income, education, age, gender and body size) prior to multivariable modelling. The resulting model was then validated using a distinct, geographically similar sample of Indigenous people living in Hamilton, Ontario, Canada.


Results:

The multivariable model of risk factors associated with prevalent CVD included age, diabetes, hypertension, body mass index and exposure to discrimination. The combined presence of diabetes and hypertension was associated with a greater risk of CVD relative to those with either condition and was the strongest predictor of CVD. Those who reported previous experiences of discrimination were also more likely to have CVD. Further study is needed to determine the effect of body size on risk of CVD in the urban Indigenous population. The final model had good discriminative ability and adequate calibration when applied to the Hamilton sample.


Conclusion:

Our modelling identified hypertension, diabetes and exposure to discrimination as factors associated with cardiovascular disease. Discrimination is a modifiable exposure that must be addressed to improve cardiovascular health among Indigenous populations.

RéSUMé: OBJECTIF: Des études ont souligné les iniquités entre les populations autochtones et non autochtones en ce qui a trait au fardeau des maladies cardiovasculaires et à la prévalence des risques prédisposants qui résultent des impacts historiques et continus de la colonisation. Nous avons voulu étudier les facteurs associés aux maladies cardiovasculaires (MCV) au sein des populations autochtones vivant à Toronto (Ontario) et spécifiques à ces populations, puis évaluer la fiabilité et la validité du modèle ainsi obtenu dans une population semblable. MéTHODE: L’étude Our Health Counts Toronto a mesuré l’état de santé de départ de membres de communautés autochtones vivant à Toronto, au Canada, à l’aide d’un échantillonnage en fonction des répondants. Une approche itérative, valorisant à la fois les données d’études scientifiques, l’expérience clinique, le vécu de personnes autochtones et les mesures statistiques, a été employée pour évaluer les candidats prédicteurs des MCV (expérience autodéclarée de discrimination, identité ethnique, affections médicales, revenu, instruction, âge, genre et taille) avant la modélisation multivariée. Le modèle ainsi obtenu a ensuite été validé à l’aide d’un échantillon distinct, mais géographiquement similaire, de personnes autochtones vivant à Hamilton (Ontario), au Canada. RéSULTATS: Le modèle multivarié des facteurs de risque associés aux MCV prévalentes incluait l’âge, le diabète, l’hypertension artérielle, l’indice de masse corporelle et l’exposition à la discrimination. La présence combinée du diabète et de l’hypertension artérielle était associée à un risque accru de MCV comparativement à l’une ou l’autre de ces deux affections médicales; c’était aussi la plus forte variable prédictive des MCV. Les personnes ayant déclaré des expériences passées de discrimination étaient aussi plus susceptibles d’être atteintes de MCV. D’autres études sont nécessaires pour déterminer l’effet de la taille sur le risque de MCV dans la population autochtone urbaine. Le modèle final avait un bon pouvoir discriminant et une calibration adéquate lorsqu’il a été appliqué à l’échantillon de Hamilton. CONCLUSION: Notre modélisation a cerné l’hypertension artérielle, le diabète et l’exposition à la discrimination comme facteurs associés aux maladies cardiovasculaires. La discrimination est un risque modifiable qui doit être abordé pour améliorer la santé cardiovasculaire au sein des populations autochtones.


Keywords:

Cardiovascular disease; Discrimination; Indigenous health; Model validation; Respondent-driven sampling.

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