Structural racism and multiple sclerosis are more connected than many realize. In the U.S., Black and Hispanic communities face faster MS progression, worse health outcomes, and higher early mortality compared to white individuals. While often viewed as a disease affecting only white people, MS incidence is actually highest in Black populations. These disparities reflect the biological effects of lived experiences shaped by racism—not innate racial differences. Disparities in the incidence, prevalence and outcomes of multiple sclerosis (MS) exist in the USA, often to the detriment of Black and Hispanic people. Despite the common misconception that MS is a disease of white people, the incidence is highest in Black people. Disability accumulates faster and at younger ages in Black and Hispanic people with MS than in their white counterparts, and MS-related mortality in early and mid-adulthood is highest in Black people. These differences are often erroneously interpreted as evidence of innate racial or ethnic variations. In this Perspective, we demonstrate how race and ethnicity – social constructs with a limited biological basis that are often assigned by systems of power – can influence biology through lived experiences, a phenomenon termed ’embodiment’. We review how downstream consequences of structural racism can lead to biological outcomes strongly associated with MS susceptibility, such as imbalanced immune system development, dysregulated immune responses to the Epstein-Barr virus and childhood obesity. We also consider how inequitable health-care access and quality, combined with the younger age of onset and higher comorbidity burdens, might explain racial and ethnic disparities in MS prognosis. Our proposed conceptual model offers a roadmap for generating knowledge and implementing interventions to narrow racial and ethnic disparities in MS susceptibility and outcomes.